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Novartis to Acquire Majority Stake in Hard to Treat Diseases' (HTDS.PK) China Subsidiary H1N1 Vaccine Partner for US$125 Million

SHENZHEN, China, Nov 09, 2009 /PRNewswire-FirstCall via COMTEX/ -- Hard To Treat Diseases (HTDS.PK) , announced today that Novartis, a US$41 billion international healthcare company, is acquiring an 85% stake in HTDS' H1N1 Vaccine partner, Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd., for US$125 million. Novartis of Switzerland will begin a five-year, $1 billion China initiative with two aims: the company will dramatically increase its investment in its China R&D facility, and it will seek to make China one its top three markets worldwide. The comments were made by Novartis' CEO, Daniel Vasella, in an interview with The Wall Street Journal.
HTDS' Chinese subsidiary, Mellow Hope, is the exclusive agent of Zhejiang Tianyuan Bio-pharmaceutical for International marketing and sales. Zhejiang Tianyuan Bio-pharmaceutical has been granted a H1N1 license on September 24, 2009 by the Chinese government agency, SFDA.

Terry Yuan, HTDS' President/CEO said "We believe that when you start to appreciate what Novartis' commitment to our partner in China fully means, and the see the large financial commitment to our partner just for the China market, you can begin to appreciate the enormous value to HTDS of our exclusive international marketing and sales relationship with Zhejiang Tianyuan Bio-Pharmaceutical. Further, the more you appreciate this value, the more you will find yourself understanding our value to them when they appointed us exclusive agent for international marketing and sales. As Mellow Hope owns all of registrations, clinical trials and brands for Zhejiang Tianyuan's international markets, the new Novartis-Zhejiang-Tianyuan entity will continue to leverage our assets and expertise in its international market. The Novartis purchase was announced by Novartis-Zhejiang-Tianyuan on November 4, 2009 (see link below) . HTDS management, elected not to release this immediately, to allow the HTDS management and its advisors to digest and analyse the long term effects of this transaction for HTDS. HTDS management is very optimistic and foresees its relationship and business with Zhejiang Tianyuan will only be further strengthened by the participation of Novartis."

Novartis reports that it has made the purchase of a majority interest in Zhejiang Tianyuan through proposed acquisition of a majority stake for US$125 million to expand its human vaccines presence in China. Zhejiang Tianyuan is a privately-held vaccines company providing a competitive product portfolio and pipeline in China, where Novartis has a limited vaccines presence. Tianyuan and Novartis are to collaborate on building a vaccines industry leader targeting unmet medical needs in China, the world's third-largest vaccines market. Acquisition of 85% stake in Tianyuan for approximately US$125 million will require Chinese regulatory and government approvals.

Tianyuan is a privately-owned vaccine company offering a range of marketed vaccine products in China and R&D projects focused on various preventable viral and bacterial diseases. Tianyuan has been delivering dynamic and profitable growth, having more than doubled its net sales to approximately US$25 million in 2008.

About Hard To Treat Diseases (HTDS)

HTDS operates 2 medical subsidiaries in Mainland China (Mellow Hope) and Serbia, Europe (Slavica Bio Chem.) ()

Mellow Hope is China-based and the biggest exporter of Biological Vaccines in China. It has a product line that encompasses vaccines for influenza, tetanus, diphtheria and other diseases; Blood based products including human rabies immunoglobulin; and active pharmaceutical ingredient (or APIs) for injection such as celesta in.

In Serbia the company's primary focus involves the enhancement and modification of existing approved drugs such as "Virazole" for the purpose of chemical repair of damage to the CNS (central nervous system), MS (Multiple Sclerosis), SARS, Hepatitis C and HIV.

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Safe Harbor Statement

Information in this news release may contain statements about future expectations, plans, prospects or performance of Hard to Treat Diseases Inc. that constitute forward-looking statements for purposes of the Safe Harbor Provisions under the Private Securities Litigation Reform Act of 1995. The words or phrases "can be", "expects", "may affect", "believed", "estimate", "project" and similar words and phrases are intended to identify such forward-looking statements. Hard to Treat Diseases Inc. cautions you that any forward-looking information provided by or on behalf of Hard to Treat Diseases Inc. is not a guarantee of future performance. None of the information in this press release constitutes or is intended as an offer to sell securities or investment advice of any kind. Hard to Treat Diseases Inc.'s actual results may differ materially from those anticipated in such forward-looking statements as a result of various important factors, some of which are beyond Hard to Treat Diseases Inc.'s control. In addition to those discussed in Hard to Treat Diseases Inc.'s press releases, public filings, and statements by Hard to Treat Diseases Inc.'s management, including, but not limited to, Hard to Treat Diseases Inc.'s estimate of the sufficiency of its existing capital resources, Hard to Treat Diseases Inc.'s ability to raise additional capital to fund future operations, Hard to Treat Diseases Inc.'s ability to repay its existing indebtedness, the uncertainties involved in estimating market opportunities, and in identifying contracts which match Hard to Treat Diseases Inc.'s capability to be awarded contracts. All such forward-looking statements are current only as of the date on which such statements were made. Hard to Treat Diseases Inc. does not undertake any obligation to publicly update any forward-looking statement to reflect events or circumstances after the date on which any such statement is made or to reflect the occurrence of unanticipated events.

CONTACT: For medical and scientific dialogue inquiry only, please contact ; For any corporate matters, please contact For any retail investor relations matters, please contact , (IR); For (M&A) and Corporate Matters

SOURCE Hard to Treat Diseases

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.Hard to Treat Diseases, Inc. (HTDS) Targets Merger with Biotechnology Company
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Companies:Hard to Treat Diseases Inc..Related Quotes
Symbol Price Change
HTDS.PK 0.0006 +0.0001


{"s" : "htds.pk","k" : "a00,a50,b00,b60,c10,g00,h00,l10,p20,t10,v00", "o" : "","j" : ""} Press Release Source: Hard to Treat Diseases, Inc. On Friday November 12, 2010, 4:01 pm EST
SHENZEN, CHINA--(Marketwire - 11/12/10) - Hard to Treat Diseases, Inc. (PINK SHEETS:HTDS - News) () is targeting a merger with a Canadian biotechnology company that deals with blood transfusion products.

This biotechnology company, who wishes to remain anonymous at this stage of negotiations, is a biotechnology company that is involved in validating a product that will reduce the major side effects related to transfusions of donated blood or hemoglobin based blood substitutes. The market value for blood transfusions on the North American market is currently in excess of $14 billion USD.

There is currently a shortfall of blood available for transfusions. Serious harmful side effects exist in the use of stored donor blood; specifically, the loss of Nitric Oxide (NO) from the recipients' blood creates a hazardous condition known as vasoconstriction. Due to the demand for blood and associated transfusions, there are an increasing number of clinical trials and process being developed to counteract the loss of NO from blood.

This up-and-coming biotech company plans to demonstrate in pre-clinical tests that its product can circumvent the loss of NO from blood and improve the shelf life of stored blood for up to 42 days.

HTDS has remained silent for the past several months as it worked on this deal is pleased with this merger opportunity and feels that it may be a perfect fit alongside their current medical subsidiaries Shenzhen Mellow Hope Pharm Industrial Co., Ltd. and Slavica Biochem.

HTDS expects to be in a position to release the name of the merger candidate and the new appointee officers and all relevant data shortly. The company is of the opinion that this is a significant event that requires a public release.

More details to follow shortly.

About Mina Mar Group:

Mina Mar Group pioneered the "Go Public Free" program, the first firm to challenge the short sellers, stock bashers and repeal of the "Communication Decency Act". Visit to learn more.

Mina Mar Marketing Group, MMMG () offers publicly traded companies a full array of services such as Investor Relations and maintenance investor awareness.

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Hard to Treat Diseases Inc. (PINK SHEETS: HTDS) Slavica Bio Chem Research Group Compete for the "Best Technological Innovation 2010" Award
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Companies:Hard to Treat Diseases Inc..Press Release Source: Hard to Treat Diseases, Inc. On Tuesday November 16, 2010, 4:01 pm EST
BELGRADE, SERBIA--(Marketwire - 11/16/10) - Hard to Treat Diseases (PINK SHEETS:HTDS - News) and Slavica Bio Chem operating subsidiary are delighted to report that IBISS research group after 8 months and 5 levels of competitions passed to the semi-final level of more than 250 competitors for the annual Award "Best technological innovation in Serbia in the year 2010" announced by Serbian Ministry of Science and Technological Development.

Prof. Dr. Mirjana Stojiljkovic, a Medical Advisor of HTDS, and the leader of the team said, "We are proud that, like last year, we are again among the best realized innovation ideas in Serbia, and our innovation and the business plan are well accepted. Namely, in the contest for the Best Technological Innovation in Serbia in the year 2009, Ministry of Science and Technological Development of Republic of Serbia awarded our team the second place of all scientific projects (and the first place for biological science) competed for this prestigious award, for the establishment of novel therapeutic approach in reducing and delaying of glial scar formation, a major factor in the failure of post-injury neurological recovery after the brain and spinal cord injury. For this purpose we used RIBAVIRIN, a substance that is in human practice as an antiviral drug. Importantly, beneficial effect of D-RIBAVIRIN was retained even 30 days after the cessation of drug administration. D-RIBAVIRIN treatment could also improve survival of transplants and new connections restitution between transplanted and host tissue. This is particularly interesting for embryonic, genetically modified tissue, and stem cells transplantations. Additionally, glial scar postponing via applying of RIBAVIRIN might considerably enhance recovery after brain ischemia or removing of brain and spinal cord tumors. Considering an enormous potential and benefit of RIBAVIRIN use in therapy of fore-mentioned patients, we expect a great breakthrough at the market and attention of pharmaceutical companies."

Prof. Dr. Mirjana Stojiljkovic added: "Our team wants to thank CEOs of MMMG who, on the behalf of HTDS, came to support us during this, for us, breaking point of contest."

At the company website very soon you can find the pictures from the contest. Additional details and information will be released promptly, via regular news release or Pink Sheets filing service

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Mellow Hope (HTDS) Delivers First Batch of BIOVAC-FLU Samples to India
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Companies:Hard to Treat Diseases Inc..Related Quotes
Symbol Price Change
HTDS.PK 0.00 0.00


{"s" : "htds.pk","k" : "a00,a50,b00,b60,c10,g00,h00,l10,p20,t10,v00", "o" : "","j" : ""} Press Release Source: Hard to Treat Diseases, Inc. On Friday November 19, 2010, 4:01 pm EST
SHENZHEN, CHINA--(Marketwire - 11/19/10) - Hard to Treat Diseases, Inc. (PINK SHEETS:HTDS - News) () subsidiary Shenzhen Mellow Hope Pharm Industrial Co., Ltd. (Mellow Hope) has delivered its first BIOVAC-FLU samples to India.

Mellow Hope (), the biggest exporter of biological vaccines in China, has delivered a batch of Influenza virus vaccines, Inactivated (Split) (BIOVAC-FLU) to a company in India for sample analysis before beginning the new purchase order. The company expects to finalize the sample analysis within one month. After that a new purchase order will be signed between Mellow Hope and the partner in India. That is the first batch of BIOVAC-FLU exported to India in 2010.

Mellow Hope is pleased with this agreement and hopes that this will provide new opportunities for growth

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Hard to Treat Diseases, Inc. (HTDS) Releases the Name of Its Biotechnology Merger Candidate
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Companies:HARD TO TREAT DISEAS.Related Quotes
Symbol Price Change
HTDS.PK 0.00 +0.00


{"s" : "htds.pk","k" : "a00,a50,b00,b60,c10,g00,h00,l10,p20,t10,v00", "o" : "","j" : ""} Press Release Source: Hard to Treat Diseases, Inc. On Monday November 22, 2010, 1:30 pm
SHENZHEN, CHINA--(Marketwire - 11/22/10) - Hard to Treat Diseases, Inc. (PINK SHEETS:HTDS - News) () announces that the merger negotiations with the Canadian Biotechnology company are proceeding well, and that the merger candidate permitted HTDS to release the name and additional information about the candidate:

The merger candidate, Hb Products Inc., is a Canadian biotechnology company that deals with blood transfusion products. Hb Products Inc. is a biotechnology company that is involved in validating a product that will reduce the major side effects related to transfusions of donated blood or hemoglobin-based blood substitutes.

Hb Products Inc. focuses on treatment of serious harmful side effects existing with the use of stored donor blood, focusing specifically on solving the loss of Nitric Oxide (NO) from the recipients' blood, which creates a hazardous condition called vasoconstriction. The market for these blood products is relatively untapped and highly competitive. Due to the potential market for blood substitutes and the shortfall of available donor blood, several pharmaceutical companies have attempted to gain FDA approval for their products, but none have succeeded as of yet. Hb Products Inc. plans to demonstrate in pre-clinical tests that its product can circumvent the loss of NO from blood and improve the shelf life of stored blood for up to 42 days.

The market value for blood transfusions on the North American market is currently in excess of $14 billion USD.

HTDS sees Hb Products as a perfect fit alongside their current medical subsidiaries Shenzhen Mellow Hope Pharm Industrial Co., Ltd. and Slavica Biochem.

[mickymoose99]

.Mellow Hope (HTDS) Registration Certificate of Cognistar Approved in India
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Companies:HARD TO TREAT DISEAS.Related Quotes
Symbol Price Change
HTDS.PK 0.00 0.00


{"s" : "htds.pk","k" : "a00,a50,b00,b60,c10,g00,h00,l10,p20,t10,v00", "o" : "","j" : ""} Press Release Source: Hard to Treat Diseases, Inc. On Friday November 26, 2010, 3:45 pm EST
SHENZHEN, CHINA--(Marketwire - 11/26/10) - Hard to Treat Diseases, Inc. (PINK SHEETS:HTDS - News) () subsidiary Shenzhen Mellow Hope Pharm Industrial Co., Ltd. (Mellow Hope) announces that, after four years of continuous effort, the registration of Cerebroprotein Hydrolysate for Injection (Cognistar) has been approved by India's drug regulator, Drugs Controller General of India (DCGI).

As soon as the approval is finalized, Mellow Hope () will launch this product in the local market. Until this point there has been no local supplier in India for Cognistar, so the company anticipates healthy sales as it fills this market vacancy and claims a large market share. The company received permit to import this product to India, and copy of this certificate will be made available @ . The company will also post this certificate on OTCMarkets.Com as a filing shortly.

Cognistar is a unique nutriment for the brain. It regulates and improves nerve cell metabolism, promotes synapse generation, induces nerve cell differentiation, and protects nerve cells against damages by ischemia and neurotoxins.

The company is pleased at this approval after years of diligent research, and will keep the investor public updated as the first batches of Cognistar reach the Indian market.

In other company news and updates, regarding the news of November 22, 2010 and merger progress with a Canadian based Hb Products Inc. (Hb) the company is working diligently and vigorously to have the merger completed way ahead of the Christmas holidays. Currently a new updated web site is being developed to include Hb with a preview available at this link .

The management will release further updates shortly as they become available.

[Nicholas_B]

Thank you very much for sharing the update news.